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Topiramat Drug Information

Type of Drug

Anticonvulsant; drug used to prevent certain types of seizures

How the Topiramat product Works

Topiramate reduces the incidence of seizures by acting on the central nervous system to alter certain neurological transmissions in the brain.

Uses of The Topiramat

To treat adults and children older than 2 years of age with partial onset seizures or primary generalized tonic-clonic seizures and seizure with Lennox-Gastaut syndrome in combination with other anticonvulsant drugs.

Precautions

Use with caution in the following situations:

Pregnancy: There are no adequate and well-controlled studies in pregnant women. Use only if clearly needed and the potential benefits to the mother outweigh the possible hazards to the fetus.

Breastfeeding: It is not known if topiramate appears in breast milk. Consult your doctor before you begin breastfeeding.

Children: Safety and effectiveness in children younger than 2 years of age have not been established.

Drug Interactions

Tell your doctor or pharmacist if you are taking or planning to take any over the counter or prescription medications or dietary supplements while Tropicana. Doses of one or both drugs may need to be modified or a different drug may need to be prescribed. The following drugs and drug classes interact with topiramate:

  • Carbamazepine (eg, tegretol)

  • Carbonic anyhdrase inhibitors (eg, acetazolamide)

  • CNS depressants (eg, narcotics, hypnotics)

  • Digoxin (eg, lanoxin)

Side Effects

Every drug is capable of producing side effects. Many topiramate users experience no, or minor, side effects. The frequency and severity of side effects depend on many factors including dose, duration of therapy, and individual susceptibility. Possible side effects include:

Digestive Tract: Nausea; indigestion; stomach pain; constipation; diarrhea; vomiting; dry mouth; gingivitis; stomach or intestinal irritation; hemorrhoids; changes in taste sensation.

Nervous System: Dizziness; incoordination; speech disorders; rapid eye movement; abnormal skin sensations; tremor; drowsiness; nervousness; memory difficulty; confusion; depression; appetite loss; agitation; aggressive reaction; hallucination; apathy; slow thinking; difficulty concentrating; anxiety; sleepiness; fatigue; dizziness; mood swings.

Circulatory System: Abnormal blood counts; low blood pressure; AV block; heart rhythm changes.

Respiratory System: Sore throat; upper respiratory infection; sinus infection; difficulty breathing.

Urinary and Reproductive Tract: Breast pain (females); menstrual disorder; blood in urine; urinary tract infection; frequency of urination; uri­nary incontinence; kidney stones; impotence; difficult or painful urination.

Skin: Rash; itching; increased sweating; acne.

Other: Influenza-like symptoms; hot flushes; body odor; fluid retention; muscle pain or weakness; weight decrease; nosebleed; dehydration; abnormal vision; double vision; joint, bone, back, chest, or leg pain; increased muscle tone; decreased hearing; fever; ringing in the ears.

Guidelines for Use

  • Dosage is individualized. Take exactly as prescribed.

  • Do not stop taking or change the dose, unless directed by your doctor.

  • May be taken without regard to meals.

  • If using the sprinkle capsule, sprinkle contents on a small amount (teaspoonful) of soft food (eg, custard, applesauce, yogurt). Swallow without chewing. Do not store any of the sprinkle capsule/food mixture for later use.

  • Because of the bitter taste, tablets should not be broken, crushed, or chewed.

  • Maintain adequate fluid intake to decrease the risk of kidney stones.

  • Inform your doctor immediately of blurred vision or pain around the eye.

  • May cause dizziness, confusion, drowsiness, and difficulty concentrating. Use caution when driving or performing tasks requiring alertness, coordination, or physical dexterity.

  • Should be withdrawn gradually to minimize potential of increase in seizures.

  • Inform your doctor of prolonged periods of dialysis.

  • Consider forms of contraception other than estrogen-containing birth control pills.

  • See your doctor regularly to ensure correct dosage is being administered. Lab tests will be needed to monitor therapy.

  • Store at 59° to 86°F in a tightly sealed container. Protect from moisture.